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Disclosures: Hyunseok Kim: Nothing to Disclose, Ally Hatcher: Nothing to Disclose, Vikrant Rachakonda: Nothing to Disclose, Linda Azab: Nothing to Disclose, Touseef Qureshi: Nothing to Disclose, Lixia Wang: Nothing to Disclose, Ji Hye Min: Nothing to Disclose, Polly Kirsch: Nothing to Disclose, Yee Hui Yeo: Nothing to Disclose, Walid Ayoub: Intercept: Speaking and Teaching, Mirum: Grant/Research Support, GSK: Consultant, GSK: Grant/Research Support, Madrigal: Grant/Research Support, Cymabay: Consultant, Ipsen: Grant/Research Support, Zydus: Grant/Research Support, Alexander Kuo: Nothing to Disclose, Hirsh Trivedi: Nothing to Disclose, Aarshi Vipani: Nothing to Disclose, Yun Wang: Nothing to Disclose, Stephen Pandol: Nothing to Disclose, Ju Dong Yang: Nothing to Disclose, Shelly Lu: Nothing to Disclose, Debiao Li: Nothing to Disclose 1587 HEPATOCYTE-SPECIFIC DELETION OF BETAINE HOMOCYSTEINE METHYLTRANSFERASE PROMOTES AGE-DEPENDENT PROGRESSION OF LIVER DISEASE Poonam Sagar 1 Sathish Perumal 1 Ramachandran Rajamanickam 1 Natalia Osna 1 Karuna Rasineni 1 Kusum Kharbanda 2 , 1 University of Nebraska Medical Center, 2 Department of Veterans Affairs, Veterans Affairs Nebraska-Western Iowa Health Care System Background: Betaine homocysteine methyltransferase (BHMT), an enzyme involved in one-carbon metabolism, plays a critical role in maintaining liver health