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This result is in excellent agreement with data by Gregus and Klaasen who reported that following single IV injection of 1 mg Co(II)/kg 72.6% of non-radioactive cobalt was excreted in urine by day 4.(26) Fecal excretion peaked at 3.3% at day one post exposure and gradually reduced to 0.5% atday5

Santos, Ricardo A

doi: 10.2147/ijn.S344679 280 AhmedATaitSWG

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Therefore, the decomposition of HMPB in an acidic environment releases exogenous iron for the production of toxic hydroxyl radicals, coupled with the targeting and photothermal destruction of ferritin in a neutral cytoplasmic environment, thus collectively constituting a synergistic process