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IGF-1Eb in rodents) the mechanosensitive splice variant, expressed locally in skeletal muscle in response to stretch, overload, or damage, characterised by a 49 bp insert (52 bp in rodents) within exon 5 that creates a reading frame shift and generates a unique 2425 amino acid C-terminal E-domain peptide distinct from the E-domain of IGF-1Ea The 24-amino acid C-terminal E-domain peptide of IGF-1Ec commonly designated MGF-24aa or MGF E-peptide is the biologically active fragment studied in the majority of synthetic MGF research, including PEG-MGF

San Diego, CA: Elsevier Academic Press

& Rueda, N

Sweet spot = 2501000 mg/day because studies show that it increases glutathione levels by 17-35% (IJDVL) Timing also matters

Free from acute infections or active cancer

This activation occurs in skeletal muscle and white adipose tissue, where it suppresses glucose synthesis [95, 96]