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Finally, peripheral T-cell lymphoma (PTCL), which accounts for approximately 10% of aggressive lymphoid tumors [18], includes two common subtypes: Peripheral T-cell lymphoma (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) [19]

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Genetic polymorphisms in the HNMT gene have been associated with altered histamine sensitivity, and factors that inhibit HNMT (including certain MAO inhibitors and alcohol) can compound histamine accumulation at the cellular level