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Notably, the SI of the extract against DENV-2 was more than 10, indicating its potential as an antiviral agent

This shapes the entire dosing approach: you want enough to maximize receptor engagement, not more

J Pharmacol Sci 134(4):234238

One wonders whether precision cut liver slices have provided unique toxicological insights, or whether cross-species hepatocyte toxicity studies would have provided equally informative data had they been undertaken

doi: 10.1371/journal.pone.0005553 23 EnglerC.KandziaR.MarillonnetS

Fluorine, a highly electronegative atom, is important in medicinal chemistry, where a single fluorine incorporation in small molecules can increase pharmacokinetic and physicochemical properties, improve metabolic stability and enhance membrane permeation 41