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Description

Minocycline enhances MPTP toxicity to dopaminergic neurons

Mutations in SOD1 result in changes in the amino acid sequence at a single position

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Thorgeirsson, S

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Most importantly, targeting either GSH with the inhibitor BSO or Nrf2 through an siRNA approach or with the small molecule inhibitor ML385 sensitised resistant MRT cells to cisplatin-induced cell death suggesting that targeting the Nrf2/GSH antioxidant defence pathway may present a novel therapeutic avenue in the design of new treatment strategies for MRT and a means of overcoming chemoresistance