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On one hand, moderate HO-1 expression can degrade heme to reduce free iron, inhibit NF-KB activation, and alleviate inflammation and oxidative stress ( In addition to NF-KB and Nrf2/HO-1, the NLRP3 inflammasome and cGAS-STING pathways also play distinctive roles in ferroptosisinflammation crosstalk

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It develops when high levels of uric acid in the blood form sharp crystals in the joints

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