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In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17

We selected the most abundant clones from the respective libraries, aML5, aMD4 and aMD5 (named after the anti-Met L- or D-number of the cloned peptide), for further characterization (Supplementary Table 2)

In addition, when glutamine is limiting via glutaminase inhibitor, asparagine can modulate glutamine synthesis by up-regulating glutamine synthetase, thereby participate in the regulation of the TCA cycle

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It is important to understand that while the order in which names appear on the deed is not significant, the position of the loan is critical