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The expression of reticulon-1A (RTN1A), an ER-associated protein, was found to be elevated in diabetic kidneys of both humans and mice, and the expression of RTN1A is associated with the progression of DKD (83)

Figure 1 As one of the critical cell death pathways in SARS-CoV-2 infection, necroptosis can be orchestrated to alleviate the damage the cytokine storm causes

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In addition to cysteine and GSH depletion, our data showed a marked increase in total and mitochondrial ROS following dual inhibition, which was effectively reversed by NAC treatment