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SMDJ Seychelles Medical and Dental Journal

10.1186/s12882-018-1094-z Summary Keywords chronic kidney disease, cellular senescence, interaction, mechanism, therapy Citation Zhao J-L, Qiao X-H, Mao J-H, Liu F and Fu H-D (2022) The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity

The mTOR agonist MHY1485 partially reverses this protective effect

The fertilization rate (the number of 2PNs divided by the total number of MII oocytes), quality of obtained embryos, implantation rate (the number of intrauterine gestational sacs divided by transferred embryos), as well as clinical pregnancy rate (by detecting fetal heartbeats two weeks following the positive hCG) and ongoing pregnancy rate (a pregnancy documented by ultrasound over 20 gestational weeks that showed the presence of normal fetus)

While metformin has been demonstrated to improve mitochondrial respiration, it is worth noting that higher doses of metformin have been associated with a contrary effect, namely, reduced mitochondrial respiration

Ongoing research seeks to better understand how these biological processes contribute to maintaining cellular integrity and tissue homeostasis during aging