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ROS buildup and cellular damage are made worse by the depletion of antioxidant defenses, especially glutathione peroxidase and catalase [133]

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Firstly, less adiponectin from adipose tissue reduces the activation of CaMKK due to the downregulation of nicotinamide phosphoribosyl transferase (NAMPT), 74,95 leading to a weaker AMPK activity, which can be observed long before the onset of diabetes

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(2012) reported a lower P TPC (0.26 mgL 1 day 1 ) in L

AM-V was supported by Swedish Medical Research Council (Projects 03P-14096, 03X-14041, and 13X-10370)