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Ingestion of Host Hemoglobin via Formation of the Cytostome Unlike other microbes that source heme iron from hemoglobin through extraction from soluble and cell surface/wall receptors and subsequent transfer to cell wall and ABC transporters (Pishchany and Skaar, 2012), P

10.1182/blood-2011-06-353938 Cambon-Bonavita MA, Schmitt P, Zieger M, Flaman JM, Lesongeur F, Raguenes G, Bindel D, Frisch N, Lakkis Z, Dupret D, et al .: Cloning, expression, and characterization of DNA polymerase I from the hyperthermophilic archaea Thermococcus fumicolans

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The activated enzyme (Factor Xa) is an Arg-specific serine protease related to trypsin, but with a much narrower substrate specificity

Thus, the cells relied on the accumulated GSH prior to SSF to relieve the toxicity