l carnitine given to women midage ncbi L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial Changes in carnitine profiles during

The PM plays a central role in the perception and transmission of information about external stimuli to different subcellular compartments

FUNDING STATEMENT This work was supported by the University of Milano-Bicocca with FA (Fondo di Ateneo) to PF and MER

McDevitt M, Bucala R

The area of these fibrinaloid microclots was found to be greater in ME/CFS samples in comparison to healthy controls (313)

14 , e1724 (2024)

(e.g., tetany) For more information see Vitamin D deficiency. Vitamin D toxicity Causes Oversupplementation Granulomatous disorders (e.g., sarcoidosis): due to increased 1-hydroxylase activation in epithelioid macrophages increased 1,25-dihydroxyvitamin D synthesis Clinical features Hypercalcemia, hypercalciuria (see also laboratory evaluation of bone disease) Loss of appetite Stupor Therapeutic uses Osteoporosis (prevention and treatment) Paget disease Prenatal supplementation for vegetarian mothers (400 IU per day) Characteristics Synonyms: : tocopherol, tocotrienol Substance class: tocopherols Chemical structure: chromane with isoprenoid side chain Inactive precursors (provitamins): none Active form: tocopherol Sources: meat, eggs, vegetable oils, leafy vegetables [8] Transport: alpha-tocopherol transfer protein (-TTP) Storage: adipose tissue, parenchymal cells of the liver Excretion: via bile Functions Antioxidant Prevents free radical damage, especially in RBCs and at cell membranes Interrupts free radical chains and oxidizes itself as a result Other functions Inhibition of platelet aggregation, cell proliferation, and monocyte adhesion Enzyme inhibition (e.g., protein kinase C, phospholipase A2) Inhibition of gene transcription (e.g., for -TTP, tropomyosin alpha-1 chain) Vitamin E deficiency Deficiency is very rare