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Building upon foundational studies in nutraceutical delivery nanotechnology, we incorporate new insights from the past several years including emerging nanocarriers (lipid- and biopolymer-based), co-encapsulation of synergistic ingredients, and real-world considerations such as scale-up and regulatory status that have not been collectively examined in previous reviews

These coactivators generally orchestrate with DNA-bound transcription factors, such as nuclear respiratory factors (NRF1, NRF2), estrogen-related receptors (ERR, ERR, and ERR), and myocyte enhancer factor 2 (MEF2) to drive the expression of target genes

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This phenomenon has also been demonstrated in bone biopsies from human infections as well as in post-mortems [176], indicating that this biological process occurs both within the laboratory and during natural infection

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