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The second line of antioxidant defense is represented by diet-derived antioxidants, including vitamins C and E, carotenoids, and flavonoids

Yang CY, Chu FH, Wang YT, Chen YT, Yang SF, Shaw JF

In addition, stem cell marker expression was remarkably reduced in SDSCs from old donors (Supplementary Fig

363 In contrast, secondary resistance arises after an initial period of therapeutic efficacy, during which tumors gradually acquire resistance under ongoing selective treatment pressure, ultimately leading to disease progression or reccurence