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In sum, long-term infertility is associated with a modified methylome in euploid blastocysts with specific concentration on regulation pertaining to genomic imprinting, which is compared to aided reproductive technologies alone (Reference Denomme, Haywood and McCallie37)

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doi: 10.22074/cellj.2021.7849 90 CaoSSZimmermannEMChuangBMSongBNwokoyeAWilkinsonJEet al

To confirm that tree-based ML models are the most appropriate for our analysis we also built Least Absolute Shrinkage and Selection Operator (LASSO) models to predict circulating TMAO in the left-out group using again fivefold cross-validation with all the available variables (full model) as input in BMIS ( N = 582