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Wang Y, Zhu S, He W, Marchuk H, Richard E, Desviat LR, Young SP, Koeberl D,Kasumov T, Chen X, Zhang GF (2024) The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia

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Additionally, ketamine activates the NLRP3 inflammasome, inducing caspase-1 activation and neuronal pyroptosis, further contributing to neuroinflammation in regions, such as the hippocampus and prefrontal cortex (Zhang et al., 2021)

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Furthermore, administration of L-carnitine substantially altered the effects of TRZ and markedly reduced the expression of autophagy-related genes such as Beclin1, Autophagy Related Gene 5 (ATG5), and the inflammatory mediator TNF- in comparison to the TRZ treated group (Khedr et al

It has been reported that FDG brain hypometabolism in the pre-frontal cortex is also present in multiple neurodegenerative disorders (such as Parkinsons disease and AD) (24, 112, 113) and neuropsychiatric conditions (114)