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Panel C ) were determined using the GSH/GSSG-Glo Assay with luminescence measured by the FLx800 Multidetection Microplate Reader (BioTek)

Red flag symptoms requiring prompt medical evaluation include: Severe, persistent abdominal pain, especially if radiating to the back (possible pancreatitis) Right upper quadrant pain, fever, or yellowing of skin/eyes (possible gallbladder disease) Persistent vomiting or inability to tolerate oral intake Severe fatigue or weakness Numbness or tingling in extremities Confusion or memory problems Signs of allergic reaction Low blood sugar symptoms in patients also taking insulin or insulin secretagogues [1] Patients should never adjust Zepbound dosing or discontinue prescribed supplements without consulting their healthcare provider

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This was predominant in the male Gclc L-KO mice and was not rescued with Nrf2 deletion (Fig