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Keeling, K.M

Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells

MRI and MRSI techniques Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy imaging (MRSI) are powerful non-invasive techniques that can be used to study tissue biomarkers and complement plasma metabolomics studies

doi: 10.1016/j.exer.2022.109364 225 BiesemeierAYoeruekEEiblOSchraermeyerU

Product Specifications Compound: Glutathione (GSH, reduced glutathione) Class: Naturally occurring tripeptide antioxidant Sequence: -Glu-Cys-Gly (-peptide bond) Molecular Formula: CHNOS Molecular Weight: ~307 Da Form: Lyophilized powder Vial Size: 1500mg in 10mL glass vial Purity: 99%+ verified by HPLC and mass spectrometry (See COAs) Research Background Glutathione has been investigated in research literature across several scientific contexts: Cellular redox biology investigations into glutathiones role as the primary intracellular thiol antioxidant and its cycling between reduced (GSH) and oxidized (GSSG) forms Oxidative stress research studies examining cellular response to reactive oxygen species (ROS) and the cellular glutathione systems role in redox homeostasis Thiol biochemistry research analytical chemistry studies on glutathiones sulfhydryl group reactivity and protein S-glutathionylation in cellular research Cellular detoxification pathway research studies on glutathione-S-transferase (GST) enzymatic systems and Phase II metabolism in cellular research models Mitochondrial cellular biology research literature on mitochondrial glutathione pools and their role in cellular bioenergetics research Comparative thiol research analytical studies positioning glutathione alongside other cellular thiol compounds in cellular research contexts Glutathione is one of the most extensively characterized small molecules in cellular biology research, with foundational research spanning over a century of peer-reviewed publications across biochemistry, cellular biology, and analytical chemistry

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