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Their expression profiles have been found to be tissue type-specific and frequently deregulated in various cancers 79

10.1111/j.1742-4658.2012.08644.x 172 SemenzaG

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Hyperhomocysteinaemia can induce endothelial-myocyte uncoupling by matrix metalloproteinase activation and subsequent interstitial fibrosis accumulation, and this uncoupling leads to impaired diastolic relaxation ( Higher Prevalence of CHD In our study, combined MMA patients showed a much higher incidence of CHD of ~5.3% compared to that of 8.98 per 1,000 live births in the general population in China ( In CblC patients, because of insufficient MeCbl, the remethylation of homocysteine (Hcy) to methionine (Met) catalyzed by methionine synthase is greatly impaired, causing disturbance or disruption of the Met-Hcy-SAM pathway

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