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A CIC target binding octamer sequence occurs in the promoter regions of the folate transport genes FR, PCFT, and RFC1, and dihydrofolate reductase, and binding was confirmed by chromatin immunoprecipitation assays

Reduced and bioavailable forms: Supply glutathione in its active, reduced state, allowing cells to utilise it immediately without additional metabolic conversion (NIH)

However, there are some intriguing varia- tions in organisms such as halobacteria, in which GSH can be replaced by other sulphur compounds like g- glutamylcysteine (g-EC) and thiosulphate (Newton & Javor 1985)

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Nature 519 , 472476 (2015)