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Advantage : Neither (tie) Weight Loss Efficacy# CagriSema : REDEFINE 1 Phase 3 demonstrated 20.4% mean weight loss at 68 weeks

By enhancing hepatocyte growth factor (HGF) activity at c-Met receptors, DIHEXA promotes neural plasticity and the formation of new synapses

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As the observed branching morphogenesis would be expected to require coordinated proliferation and migration of cells, the dimeric macrocycles could fulfill the function of regenerative drugs for the repair of tissue damage or for other therapeutic uses

For example, in various cell culture lines, c-Met phosphorylation can result in downstream activation of Akt, Erk/MAPK, JNK, or FAK signaling (reviewed by Organ and Tsao, 2000