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When EWS RGGF was overexpressed in HeLa cells, however, the TERRA levels on chromosomes 1q, 9p, 15q, and XqYq were not much different than when EWS was overexpressed, suggesting that endogenous TERRA did not repress the transcriptional activity induced by overexpression of EWS

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Noctor G., Queval G., Mhamdi A., Chaouch S., Foyer C.H

IGF-1 has also been shown to protect cochlear HCs by activating the PI3K/Akt and MEK/ERK pathways, thereby improving hearing [154]

These findings suggest that targeting RIPK1 may represent a potential strategy for intervening in retinal degenerative diseases, such as AMD, and highlight the importance of combining multiple markers to distinguish between different types of cell death