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Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng D-S, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB (2008) Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

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In contrast, iron overload induced significant downregulation of ACSL4 and GPX4 expression in these cells, suggesting a disruption in lipid homeostasis and a reduction in antioxidant defense mechanisms, which may contribute to the progression of iron-induced ferroptosis

For instance, the triple negative breast cancer cells MDA-MB-231 release miR-105-rich EVs that force CAFs to up-regulate c-Myc, thus reprogramming CAFs metabolism to increase glutaminolysis and glycolysis