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Results from a commercial kit (purchased from Roche) measuring cell survival by detecting leakage of lactate dehydrogenase (LDH) were found to be misleading for this cell model Comparison of results obtained from the two different methods showed that the LDH detection did not correlate with the NR assay for all inducers tested and was not correlated with obvious morphological changes observed by light microscopy

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Acknowledgements We thank all the members of the Ferrology Innovation Center, past and present,for their fruitful discussions over the years, many of which are reflected here

Future research should address its pharmacokinetics, safety profile, and clinical potential