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in 2004 in Nature

Clinical Evidence in the Matrixyl vs GHK-Cu Comparison Evaluating the clinical evidence in the Matrixyl vs GHK-Cu literature requires distinguishing between cosmetic clinical trials (which evaluate consumer-visible outcomes like wrinkle depth) and biomarker-based research studies (which measure gene expression, protein synthesis, and cellular function)

doi: 10.1055/s-0029-1220724 52 DuntasLH

TGF1 ( responsible for liver cell growth and division), E2F1 ( cell proliferation) and HMBS (catalyzes synthesis of hydroxymethylbilane synthase) were significantly up and downregulated, respectively