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Despite your best efforts, sometimes the results just don't show up as expected

In adults with DS at age between 20 and 30 yr, A deposits are in the form of diffuse plaques, although plaque deposition already is evidenced at younger ages and is followed by neuritic plaques in the fourth decade of life (469, 470)

doi:10.1093/clinchem/hvad022

American College of Chest Physicians/Society of Critical Care Medicine

4a,b and related panels in ESM Fig

Pyocyanin induces oxidative stress by generating reactive oxygen and nitrogen species which disrupt essential defense mechanisms in respiratory epithelium