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The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia

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Furthermore, studies using DSSinduced colitis models demonstrated significantly increased syn expression in the colon and notable syn deposits in the brain [132], supporting the hypothesis that the gastrointestinal tract serves as an initial site for syn pathology, which may then propagate to the CNS via the vagus nerve [23]

Schweizer, U., Weitzel, J

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In many bacteria, the reactions of the -oxidation cycle can be carried out by multiple proteins (FadA to FadM), with FadE as the acyl-CoA dehydrogenase, FadB as the dual enoyl-CoA hydratase and 3-hydroxylacyl-CoA dehydrogenase, and FadA as the 3-ketoacyl-CoA thiolase (see Fig 1