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El correcto balance de tetrahidrofolato puede ser recuperado por la accin de la metionina sintasa o tambin a partir del folato fresco por ingesta

Clinical Medicine Insights: Cardiology (2017) 7

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An important risk factor for cardiovascular disease (CVD) that can be removed with vitamin B12 and folic acid supplementation is the hypothesis that any major folate-sensitive abnormality in homocysteine metabolism may lead to diminished methylenetetrahydrofolate reductase activity Patients with mild to moderate CKD and higher B12 levels who received folic acid treatment saw a greater decline in their risk of CKD progression