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Stress induction iRPE cells were exposed to FeCl 3 NTA (1 mM) or 4HNE (120 M) for 24 h, and TF (1020 mg/mL) was co-administered with the stress inducer

These results were consistent with the reports showing that M1 macrophages were protected from ROS-induced DNA damage as a result of increased expression of multiple antioxidant genes, such as superoxide dismutase 2 (SOD2) [95, 96]

JV, AS, SS, and PS: writingoriginal draft, review, and editing

Its protein structure takes the form of a tetramer composed of a complex of 4 identical subunits, each containing 527 amino acid residues and a heme group with Fe 3 + [22, 23]

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Therefore, interventions that sustain D-serine levels or NMDA signaling might improve neural reinnervation in older adults