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Tryptase and urinary mast cell mediators will be highlighted in this review as they are currently the most clinically available and studied biomarkers of mast cell activation

Sibutramine has only little clinical relevance as an antidepressant but enhances weight loss due to an increase in energy expenditure and inhibition of food intake (37)

2005;288:R1220R1225

Kwak, M.K., et al.,Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathway

Lipid peroxidation, DNA damage, and protein oxidation within spermatozoa result from OS, which occurs due to an imbalance between endogenous antioxidant defenses and reactive oxygen species (ROS) generation [2, 3]