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However, the majority of subsequent studies in larger samples have failed to replicate this effect with low opioid drug doses (Table 2), although some impairments in logical reasoning have been observed with medium and high doses of full and mixed agonists (Figure 3, right panel)

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Real-world evidence suggests favorable cardiovascular effects, with some retrospective analyses showing tirzepatide may reduce major cardiovascular events by approximately 14% compared to semaglutide

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