glutathione and glutathione-s-transferase in detoxification mechanisms Homeostasis Functions: Potential Targets for Medical Interventions - Lushchak - 2012 - Journal of Amino Acids Heavy metals detoxification mechanism; SOD,

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Decreased serotonin release and serotonergic fiber density are observed especially in the hippocampal region of 5xFAD mice (Tian et al., 2023), a feature also seen in depressive rats following intracerebroventricular injection of soluble A-42 (Colaianna et al., 2010)

While substantial research has focused on the molecular mechanisms conferring chemoresistance, our study highlights a distinct, underexplored phenomenon: ferroptosis-activating metabolites, particularly acrolein, can interfere with the efficacy of chemotherapeutics by inhibiting necroptosis

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