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10.1158/1055-9965.EPI-11-0079 72

Acknowledgements This work was supported by the grants from National Key Research and Development Project (2018YFE0113500 to J.X.), National Natural Science Foundation of China (82020108002 and 81911540486 to J.X., 81970335 and 82170285 to Y.H.B.), the grant from Science and Technology Commission of Shanghai Municipality (21XD1421300 and 20DZ2255400 to J.X.), the Dawn Program of Shanghai Education Commission (19SG34 to J.X.), Shanghai Rising-Star Program (19QA1403900 to Y.H.B.), and the grant from Science and Technology Commission of Shanghai Municipality (21SQBS00100 to Y.H.B.)