glutathione synthetase deficiency prevalence dysregulation and the etiology and progression of human diseases Frontiers | Glucose-6-Phosphate Dehydrogenase Deficiency

This shift is consistent with the SECs are in a state of cellular senescence or quiescence with an increased focus on maintaining existing protein function through post-translational modification (dephosphorylation) and tightly controlling gene expression (mRNA regulation), which is consistent with the characteristic dysfunction and loss of regenerative capacity seen in aged endothelium

[1] What the best bioavailability trial actually showed The most rigorous test of this question was a six-month, randomized, double-blind, placebo-controlled trial of oral glutathione at 250 or 1000 mg/day in 54 non-smoking adults

Chebolu, S., Wang, Y., Ray, A

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Extrapituitary expression of GH has been detected in the human retina and vitreous fluid, 94 and GH has been demonstrated to directly stimulate the proliferation of human retinal microvascular endothelial cells in vitro