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Current clinical guidelines from major professional organizations provide evolving recommendations for pharmacologic management of weight regain after bariatric surgery

But the mechanism is well-characterized and the target (NNMT in adipose tissue) is a legitimate pathway for visceral fat reduction

If the vial is exposed, keeping it in a dark area of the refrigerator is a simple precaution

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Some clinics pivoted to recommending FDA-approved alternatives for weight management, including GLP-1 receptor agonists such as semaglutide (Wegovy) and tirzepatide (Zepbound), both of which have extensive Phase III data and FDA-approved labels

Values show the difference from untreated control (n=3 except for NMN+hCD38+isa where n=4 biologically independent samples)