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Description

This synergy between transcription factors reinforces cellular redox balance, counteracts oxidative DNA damage, and inhibits melanoma cell proliferation 160

2011;6:e26575

All-atom empirical potential for molecular modeling and dynamics studies of proteins

[PMC free article] [PubMed] [Google Scholar] Meydani N., Meydani M., Blumberg J

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways