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While the analysis of the entire PD cohort (including de novo patients and treated patients) in addition to the de novo patient-specific analysis allowed us to maximize statistical power to detect PD-associated changes, we also performed a dedicated analysis for treated patients only, using the same filtering and adjustment steps as for the entire PD dataset, to better distinguish changes in treated from treatment-nave patients

Zinc slows down oxidative processes in the body and also inhibits aromatase and 5-reductase, which are necessary for testosterone metabolism (155)