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TGF- effects in IPF pathogenesis include alveolar epithelial injury, activation of fibroblasts, myofibroblast transdifferentiation, excessive production of ECM, and inhibition of ECM degradation

As these enzymes have a key role in the natural turnover of airway mucus, high biocompatibility is promised

References Cereda E., Malavazos A.E., Caccialanza R., Rondanelli M., Fatati G

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doi: 10.1016/j.addr.2006.09.017, 117

Parallel Signaling through PI3K/AKT/mTOR Mediates Resistance to MEK Inhibition in Preclinical Models of Acute Myeloid Leukemia (AML): Synergistic Effects of Combined MEK and mTOR Inhibition