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doi:10.1016/S0065-2113(08)60504-0

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PROEX 165.0/20) and carried out in compliance with the guidelines in RD53/2013 (Spain)

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Reversing Atrophy: By stimulating alpha motor neurons, we prevent the muscle wasting associated with "cocooning." Myokine Release: High-intensity contraction releases Irisin , a myokine that crosses the blood-brain barrier and triggers BDNF release

They create OS (high level of hydrogen peroxide, and decrease the level of catalase enzyme and glutathione peroxidase enzyme) (Agrawal et al., 2004), which leads to ER imbalance (Guan et al., 2015), caused by damage to poly unsaturated fatty acids of the cell membrane and break the disulfide bonds in proteins, that cause an accumulation of unfolded proteins in the ER