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This pro-angiogenic effect involves stimulation of vascular endothelial growth factor (VEGF) production and activation of endothelial cells to proliferate, migrate, and form new capillary networks

Vitamin C mechanisms involve serving as enzymatic cofactor for collagen hydroxylation and providing direct antioxidant protection, creating effects requiring ongoing application for maintaining antioxidant benefits but potentially supporting durable collagen improvements if used sufficiently long

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