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Glutathione stabilizes the inner mitochondrial membrane, squelches reactive oxygen species (ROS) generated by mitochondrial respiration, and maintains mitochondrial DNA fidelity to profoundly influence mitochondrial function and cell survival

Some S- mycothiolated proteins are conserved and abundant targets for S -thiolations across Gram-positive bacteria, including ribosomal proteins, GuaB, SerA and MetE 9, 10

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If so, these in vitro and in vivo systems would be conducive to interrogate the mechanisms by which vessels become insensitive to VEGF inhibition though use of shRNA/siRNA knockdowns