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Experimental evidence points a multifactorial etiology, linking hyperglycemia with the activation of multiple cell phenomena such as polyol pathway, advanced glycation end-products formation, protein kinase C (PKC) and nuclear factor K signaling, among many others (Pacher, 2008

[1] Effect of Epithalamin on the lifespan of fruit flies, mice and rats Anisimov VN, et al

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Signals and genes induced by angiogenic growth factors in comparison to inflammatory cytokines in endothelial cells