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Well, thats partially true - the beta-carotenes found in carrots can indeed cause a condition which discolours your skin, only youd have to eat a minimum of 10 carrots a day for at least a few weeks to see this happen

The reviewer GM declared a shared affiliation, with no collaboration, with the authors to the handling editor at the time of the review

10.1038/ncomms5664 138 MitrovicI.Margeta-MitrovicM.BaderS.StoffelM.JanL

[46] [47] Cancer [edit] Chronically insufficient intake of folate may increase the risk of colorectal, breast, ovarian, pancreatic, brain, lung, cervical, prostate, oesophageal, oral and pharyngeal cancers

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Laboratory testing helps us see if the dosage is right or if changes are needed