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The cochrane collaborations tool for assessing risk of bias in randomised trials

Grubman et al., 2019

Studies have demonstrated that astaxanthin treatment can alleviate mitochondrial dysfunction and rescue kidney function via its antioxidant activities in several kidney diseases, such as DKD (Naito et al., 2021) and bisphenol A-induced kidney toxicity (Jiang et al., 2020b)

Produces a depletion of releasable neuronal monoamine neurotransmitters Reserpine's effects produce a reduction in blood pressure due to a decreased cardiac output & decreased peripheral vascular resistance Figure 1

Therefore, we hypothesized that a combination of supplements (one targeting nitric oxide bioavailability (AAL-anti-atherosclerotic liquid), one targeting systemic inflammation (AIC- anti-inflammatory capsules), and one providing broad antioxidant support (AOL- antioxidant liquid)) would yield a more comprehensive and synergistic benefit than any single agent alone

This leads to the production of free radicals, destroying mitochondria, affecting energy metabolism, and forming a vicious cycle