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Non- compartmental pharmacokinetic parameters were calculated from serum drug concentration- time profiles by use of WinNonlin software (Pharsight, Mountain View, CA, USA)

An increased level of tau phosphorylation at Ser396 was observed in the presence of 5 M A 2535 , while the pretreatment with noopept caused the decline of p-tau Ser396 level (p = 0.0024) (Figure 4)