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As central regulatory nodes linking glycolysis and mitochondrial metabolism, PDKs act as critical metabolic gatekeepers that orchestrate metabolic plasticity and modulate cellular adaptation to cisplatin-induced stress, ultimately influencing the therapeutic response [37]

Combining therapies may also affect total cost and scheduling

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[PUBMED Abstract] Schrappe M, Reiter A, Ludwig WD, et al.: Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90