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MMP-9 activity was shown to exacerbate the loss of barrier integrity, facilitate the infiltration of more inflammatory cells, and contribute to the overall tissue remodeling and ulceration characteristics of severe mucositis (123)

[Abstract]2025 Dec;31(12):e70661

Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis

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Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors