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The lipid peroxidation is a free radical-driven reaction that primarily affects polyunsaturated fatty acids (PUFAs) in cell membranes, the product of which gradually increases during the ferroptotic cell death, from the initial lipid hydroperoxides (LOOHs) to the later production of malondialdehyde (MDA) and 4-hydroxynenoal (Kagan et al., 2017)

Although vitamin K has a low potential for toxicity, it can interact with certain medications, such as warfarin and antibiotics ( SUMMARY Both water- and fat-soluble vitamins can cause side effects when taken in high doses, with some causing more severe symptoms than others

The nuclear p50 ATF6 forms homodimers or heterodimers with its homolog ATF6 (84) and both of them can associate with nuclear transcription factor Y (NF-Y) to form transcriptional complexes (85)

Biomed Pharmacother = Biomed Pharmacotherapie (2018) 106:1098107

Of note, NF-B-mediated inflammation is often via the inflammasome and is associated with many white matter associated diseases and is upregulated in the aged brain (Tilstra et al., 2011

Yimam et al