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In essence, each component supports different steps of metabolic pathways, for example, energy generation from carbohydrates and fats requires B, B, B, and B in sequence

17eg), suggesting its initial antioxidative role

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As we age, mitochondrial function can decline, leading to reduced energy production and a metabolic slowdown

Since the chemical formulas were known for each labeled metabolite from the LCMS results, we first calculated the theoretical m/z values of all 12 C-metabolites with potential adduct ions, including [M + H] + , [M + Na] + , [M + K] + , [M + NH 4 ] + , and [M + H H 2 O] + in positive ion mode and [M H] , [M + Cl] and [M H H 2 O] in negative ion mode (Supplementary Table 1)